Two year funding to enable further understanding of the role of macrophages in tuberculosis infection.

•	B.C. Childhood Lung Disorders Association Fellowship 2000-2002.

Ph.D. Funding at the National Institute for Medical Research in London, England

•	MRC (U.K.) Ph.D. Fellowship 1996-1999.

An 8 month award to study the role of the immune system in Plasmodium falciparum (malaria) infection in humans.

•	MRC (U.K.) Sandwich Student Award. 1993-1994.

The NIMR does not award its own degrees. The awarding body was University College London

"Discovery and optimization of a new class of pyruvate kinase inhibitors as potential therapeutics for the treatment of methicillin-resistant Staphylococcus aureus infections"

Liver-X-Receptor and Progesterone Receptor activation promote apolipoprotein E secretion from CCF-STG1 astrocytoma cells.

Abstract 2187: Pan-cancer identification and prioritization of cancer-associated differentially expressed genes: A biomarker discovery application.

: A Pan-Cancer Analysis of Alternative Splicing Events Reveals Novel Tumor-Associated Splice Variants of Matriptase.

Innate defense regulator peptide 1018 protects against perinatal brain injury.

Discovery of a 1,2-bis(3-indolyl)ethane that selectively inhibits the pyruvate kinase of methicillin-resistant Staphylococcus aureus over human isoforms.

Abstract B065: The RSK/YB-1 pathway represents an opportunity for targeting TNBC and holds promise of treating metastases.

Hormonal modulators of glial ABCA1 and apoE levels.

A Quantitative Method for the Specific Assessment of Caspase-6 Activity in Cell Culture.

The Commensal Streptococcus salivarius K12 Downregulates the Innate Immune Responses of Human Epithelial Cells and Promotes Host-Microbe Homeostasis.

An anti-infective peptide that selectively modulates the innate immune response.

Two-dimensional DNA displays for comparisons of bacterial genomes.

The role of multiple SOS boxes upstream of the M. tuberculosis lexA gene – identification of a novel DNA-damage inducible gene.

Two-dimensional bacterial genome display: A method for the genomic analysis of mycobacteria.

Definition of the Mycobacterial SOS Box and Use To Identify LexA-Regulated Genes in.

Two-dimensional display and whole genome comparison of bacterial pathogen genomes of high G+C DNA content.

I obtained my PhD studying the cause of TB. I emigrated to Canada and did a post-doctoral position at UBC again studying TB. After my post-doctoral position I served as a Project Leader for Inimex Pharmaceuticals Inc on a project funded by the Bill Gates Foundation.  I have a strong track record in developing robust animal models of human infections. 

As Division Head of Target Validation at the Centre for Drug Research and Development (CDRD) my responsibilities include the development of cutting edge assays to facilitate the identification of biomarkers of interest to develop as companion diagnostics for clinical trial drug candidates. My team has now facilitated several such assays that are enabling biotechnology companies in Canada to develop new drugs in several indications. In addition I execute project plans for Centre for Drug Research and Development (CDRD) projects. Oversee scientific activities for projects and ensure appropriate resourcing for key POC experiments to be conducted.

Drug Development

Infectious Disease Biology

Molecular Genetics of Gene Expression

Immunohistochemistry

Antibiotic development

Tuberculosis infections

Staphylococcus aureus infections

Cell Culture

Protein Chemistry

Drug Discovery

Molecular Biology

MRSA infections

Life Sciences - Biotech and Pharmaceuticals

MAO-B Selective Inhibitor Compounds, Pharmaceutical Compositions Thereof and Uses Thereof

Anti-Bacterial Pyruvate Kinase Modulator Compounds, Uses and Methods

ANTIBIOTIC COMPOUNDS, PHARMACEUTICAL FORMULATIONS THEREOF AND METHODS AND USES THEREFORE

Head, Target Validation

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