Evaluation of secretomes derived from human dermal and adipose tissue mesenchymal stem/stromal cells for skin wound healing: not as effective as cells

Human adipose-derived mesenchymal stromal cells from face and abdomen undergo replicative senescence and loss of genetic integrity after long-term culture

Mesenchymal stromal cells from dermal and adipose tissues induce macrophage polarization to a pro-repair phenotype and improve skin wound healing

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University of Florida

Helena Zomer has more than 14 years of research experience in cellular and molecular biology with a primary focus on regenerative medicine. Her major research interest has been in studying factors leading to robust tissue regeneration using skin wound healing as a model. Because chronic skin wounds disproportionally affect older adults, her current focus is on understanding the biology of aged skin wounds. Helena's unusual background (DVM, MS, PhD) gives her a unique perspective and set of skills to answer her research questions. As a veterinarian, she follows the concept of One Health — the multidisciplinary collaborative efforts to attain optimal health for people, animals, and our environment — so that her research uses her clinical veterinary training in service of both human and animal health.

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