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UF scientist studies muscle loss in space to benefit astronauts and patients on Earth

Oct 22, 2025

3 min

Astronauts traveling to Mars will face many challenges, but one of the most serious is muscle loss during long space missions. A new study led by University of Florida researcher Siobhan Malany, Ph.D., sheds light on how human biology changes in microgravity and could help protect astronaut health while also offering hope for patients with muscle-wasting diseases on Earth.

Malany, an associate professor in the College of Pharmacy, a member of UF’s Astraeus Space Institute, and director of the in-space Biomanufacturing Innovation Hub, recently published findings showing how muscle cells adapt in space. Her team studied bioengineered three-dimensional muscle tissues derived from biopsy cells from both younger and older individuals and observed how they responded to electrical stimulation in microgravity.

These micro-scale tissues called “tissue chips” were given nutrients and electric pulses autonomously in a miniature laboratory the size of a shoe box called a CubeLab.x. A camera system inside the box recorded the rate of muscle contraction.

“This research is about more than just space,” Malany said. “By understanding how muscle tissue deteriorates much faster in microgravity, we can uncover new strategies to address muscle loss that occurs naturally with aging and with age-related diseases here on Earth.”

Siobhan Malany studies the effects of microgravity on human muscle biology using an automated tissue chip system.

View her profile here

The study found that younger muscle tissue showed more pronounced changes in mitochondrial pathways — cellular systems that produce energy — than older tissue did when exposed to microgravity. Researchers also discovered that, on Earth, older muscle tissue responds less to electrical stimulation than younger tissue. But in space, the younger tissue showed a noticeable drop in its ability to contract, suggesting that younger muscle may experience a greater change when exposed to the space environment.

These insights may help researchers design new treatments to protect muscles in astronauts during long missions, as well as develop therapies for people experiencing age-related muscle loss on Earth.

The project was part of UF’s broader efforts to advance space biology. Through the Astraeus Space Institute, UF brings together experts across disciplines, from medicine and pharmacy to engineering and plant science, to address the unique challenges of space exploration.

“UF researchers are helping lay the groundwork for humanity’s next giant leap,” Malany said. “It’s exciting to see our work contribute to both the health of astronauts and the lives of patients back home.”

UF’s leadership in space biology is strengthened through collaboration with partners including the Kennedy Space Center Consortium and the Center for Science, Technology and Advanced Research in Space), both initiatives bringing together universities in Florida’s high-tech corridor, government agencies and industry leaders. Malany’s work also builds on long-term collaborations with AdventHealth, using donated tissue samples to model age-related muscle changes in space. Her team also works with SpaceTango, a NASA-certified aerospace company, to design the CubeLab that flew to the International Space Station on multiple SpaceX missions.

Looking ahead, Malany and her team are developing new ways to study astronaut-derived cells, including both skeletal and heart muscle, generated from blood samples. These “avatars” could help researchers track changes before, during and after space missions, providing an unprecedented window into how microgravity affects the human body.

“Now we can study cells from individual astronauts and see how they respond over time,” Malany said. “This helps us understand the risks of long-term spaceflight and also gives us a platform for testing potential treatments for muscle-wasting conditions on Earth.”

By using tissue chips, small, bioengineered devices that mimic the structure and function of human organs, scientists in space can gather data more quickly and accurately than with traditional animal studies, potentially accelerating the discovery of therapies for aging-related muscle loss.

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Siobhan Malany

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Siobhan Malany studies the effects of microgravity on human muscle biology using an automated tissue chip system.

SpaceAge-related Msucle AtrophyDrug Discovery and ScreeningSpace MedicineHuman Muscle Biology

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