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The University of Florida’s ‘AI Queen’ is using AI technology to help prevent dementia

Nov 28, 2025

4 min

To help the 50 million people globally who live with dementia, the National Institute on Aging is finding researchers to develop tech-based breakthroughs that target the disease — researchers like the University of Florida’s “AI Queen.”

It’s a fitting nickname for Aprinda Indahlastari Queen, Ph.D., who is applying artificial intelligence technology to study transcranial direct current stimulation, or tDCS — a technique that involves placing electrodes on the scalp to deliver a weak electrical current to the brain — as a possible way to prevent dementia.

The assistant professor in the UF College of Public Health and Health Professions’ Department of Clinical and Health Psychology is using UF’s supercomputer, HiPerGator, to perform neuroimaging and machine learning analyses to study how anatomical differences may affect tDCS outcomes.

“Investigating working memory in patients with mild cognitive impairment offers an opportunity to understand how cognitive processes are disrupted in the early stages of Alzheimer’s disease,” said Queen, whose study — funded by a National Institute on Aging research career development grant — integrates neuroimaging with information on brain structure that is unique to older adults and those with mild cognitive impairment.

Refining the treatment with AI

Using neuroimaging, Queen captures real-time changes during tDCS to the parts of the brain associated with working memory, which is the type of memory that allows humans to temporarily keep track of small amounts of information. Think of this as a mental “scratchpad.” Her study includes older adults with mild cognitive impairment as well as individuals who are cognitively healthy.

In tDCS, a safe, weak electrical current passes through electrodes placed on a person’s head. The stimulation is being used in research and clinical settings for a variety of conditions and has shown partial success as a nonpharmaceutical intervention that can improve cognitive and mental health in older adults. But tDCS results can vary across individuals, and the suspected cause is both simple and complex: Everyone’s head is different.

“One potential reason tDCS may not work for some individuals is the variation in head tissue anatomy, including differences in brain structure,” Queen said. “Since electrical stimulation must travel through multiple layers of tissue to reach the brain, and every individual’s anatomy is unique, these differences likely affect outcomes.”

To address this further, Queen is using AI.

“Artificial intelligence will play a major role in the modeling pipeline, including constructing individualized head models, conducting predictive analyses to identify which participants will respond to the stimulation, and disentangling multiple individual factors that may contribute to these outcomes,” Queen said.

An estimated 10 to 20% of adults over age 65 have memory or thinking problems characterized as mild cognitive impairment. Their symptoms are not as severe as Alzheimer’s disease and other dementias, but they may be at increased risk for developing dementia.

“The fact that not all individuals with mild cognitive impairment progress to Alzheimer’s disease emphasizes the need to identify effective interventions that can slow the progression to dementia,” Queen said. “This project presents an opportunity to differentiate between multiple types of mild cognitive impairment and investigate how tDCS affects the brain across these subtypes.”

An AI visionary

Queen, who joined the UF faculty under the university’s AI hiring initiative, is an instructor in the College of Public Health and Health Professions’ undergraduate certificate program in AI and public health and health care, and the co-chair of the college’s AI Workgroup. She is also the assistant director for computing and informatics at the UF Center for Cognitive Aging and Memory Clinical Translational Research and a member of UF’s McKnight Brain Institute.

Queen received her Ph.D. training in engineering with a focus on building and running computational models to investigate medical devices. She experienced a career “a-ha” moment as a postdoc, when she was a co-investigator on a large clinical trial that paired brain stimulation with cognitive training to enhance cognition in older adults.

“This experience was transformative for me. I had the chance to interact directly with participants, which was both fulfilling and eye-opening. These interactions allowed me to see the immediate, real-world implications of my work and sparked a passion for pursuing aging research,” Queen said. “I realized that, through this type of research, I could have a more direct impact on addressing age-related challenges, which prompted a shift in my career plans.”

The new grant will help Queen further improve her understanding of the neurobiology and progression of Alzheimer’s disease and other dementias.

“These experiences will ultimately prepare me to become a well-rounded aging investigator, capable of making meaningful contributions to the field of aging research,” Queen said.

She also credits her mentors and collaborators — Ronald Cohen, Ph.D.; Adam Woods, Ph.D.; Steven DeKosky, M.D.; Ruogu Fang, Ph.D.; Joseph Gullett, Ph.D.; and Glenn Smith, Ph.D. — with supporting her as an early career scientist.

“It really takes a village to get here!” Queen said.

Connect with:

Aprinda Indahlastari Queen

Assistant Professor

Aprinda Indahlastari focuses on achieving precision medicine by improving existing medical devices/intervention methods.

Cognitive AgingtDCSComputational NeuroscienceFinitie Element MethodsNeuromodulation

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Dec 11, 2025

1 min

Opinion: Hey Florida! Want to go to Mars? Here’s what it will do to your body

The president is eager “to plant the stars and stripes on the planet Mars.” Would you sign up for that mission? What would happen to your body in the three years you would be gone? As the United States continues to prioritize space travel, you might wonder why anyone would want to travel to Mars and whether it’s even ethical to expose humans to such extreme physiological conditions. The world is watching as the astronauts on the Boeing Starliner remain stuck in space until at least March due to a capsule malfunction. So many questions have arisen about the impacts of people spending extended periods of time in space, and we don’t have all the answers yet. However, because I study how spaceflight affects human physiology and performance, I have some ideas. The first 10 minutes of your journey will be exciting, but it’s the next months and years we really need to worry about. We have solved some of the problems but not all. After you lift off, the high g-forces will paste your body against the crew couch as you accelerate, but there’s really not too much to fear. A typical launch results in only about half the acceleration experienced by a fighter pilot in a tight turn. You might feel lightheaded, but astronauts have dealt with this for generations. Read the full article in the Tampa Bay Times here:

Dec 10, 2025

3 min

As holiday shopping season nears, UF experts warn retail theft is growing more sophisticated

With the busiest shopping season of the year approaching, new findings from the National Retail Federation’s Impact of Retail Theft and Violence 2025 report — developed by the University of Florida’s SaferPlaces Lab and the Loss Prevention Research Council — show retailers are facing increasingly complex and technology-driven threats. UF researchers say early preparation, better data and stronger collaboration will be essential as stores brace for heavier foot traffic and heightened safety risks. Despite public reports that retail theft is decreasing, Read Hayes, Ph.D., a UF research scientist and director of the LPRC at UF Innovate, said retailer surveys tell a different story: Incidents of shoplifting, organized retail crime, online fraud and other external theft continue to rise, even as some law enforcement statistics appear flat or declining. The gap, he said, reflects how much crime goes unreported or unrecorded. “Retailers have always had a difficult time reporting much of their crime, and if you look only at police data, like calls for service or arrests, it can look like retail crime is flat or even slightly down,” he said. “But when we survey retailers, who are the actual crime victims, they consistently report year-over-year increases in theft and violence.” Criminal groups are also becoming more sophisticated. Hayes said offenders are increasingly using technology to defeat protective systems, disrupt cameras and identify vulnerable stores. They also rely heavily on social media platforms such as TikTok and Reddit to coordinate attacks and share tactics. “It’s a little disconcerting how much criminals rely on social media now to scout stores, map out easy targets, learn from each other or just plain brag about how they did it,” he said. LPRC scientists monitor social media signals to help retailers and law enforcement understand emerging threats — not in real time, Hayes said, but to help build best practices organizations can use to defend themselves. Criminals continue to focus on high-demand items such as branded apparel and footwear, prompting retailers to rethink how those products are displayed and secured. Hayes said many companies are testing new approaches to better protect vulnerable merchandise without driving customers away. One example is automated self-service systems for locked items, where customers can retrieve a product by having a code sent to their phone without waiting for a store employee. Safety remains retailers’ top concern, Hayes said. LPRC’s latest report, developed in collaboration with the security technology company Verkada, found that frontline retail workers report feeling less safe than ever, a trend that typically intensifies during the holiday rush. Rising incidents of in-store violence, limited law enforcement support in some areas and increased guest-related confrontations are pushing retailers to reassess how they protect both employees and customers. “Nothing is more important than protecting the frontline retail associates who keep this industry running,” Hayes said. “This report helps reinforce what retailers need to do to ensure those workers feel safe.” LPRC teams are also studying ways to improve safety beyond store walls, testing parking lot technologies, including license plate readers and flashing deterrent systems designed to discourage potential offenders and reassure law-abiding shoppers. At the federal level, Hayes said he and partners across the country are urging Congress to pass a bill to address organized retail crime and establish a centralized platform for reporting retail theft threats. As the holiday season approaches, Hayes said the need for evidence-based solutions has never been clearer. “Retailers are under pressure to keep their stores safe, welcoming and competitive,” Hayes said. “The more we can understand offender behavior, customer expectations and emerging technologies, the better we can help retailers, communities and law enforcement reduce harm.” The LPRC, headquartered at UF Innovate, brings together more than 200 major retailers, technology companies and public safety agencies to conduct research that strengthens store safety, reduces loss and enhances the customer experience.

Dec 8, 2025

1 min

AI Can’t Replace Therapists – But It Can Help Them

For a young adult who is lonely or just needs someone to talk to, an artificial intelligence chatbot can feel like a nonjudgmental best friend, offering encouragement before an interview or consolation after a breakup. AI’s advice seems sincere, thoughtful and even empathic – in short, very human. But when a vulnerable person alludes to thoughts of suicide, AI is not the answer. Not by itself, at least. Recent stories have documented the heartbreak of people dying by suicide after seeking help from chatbots rather than fellow humans. In this way, the ethos of the digital world – sometimes characterized as “move fast and break things” – clashes with the health practitioners’ oath to “first, do no harm.” When humans are being harmed, things must change. As a researcher and licensed therapist with a background in computer science, I am interested in the intersection between technology and mental health, and I understand the technological foundations of AI. When I directed a counseling clinic, I sat with people in their most vulnerable moments. These experiences prompt me to consider the rise of therapy chatbots through both a technical and clinical lens. AI, no matter how advanced, lacks the morality, responsibility and duty of care that humans carry. When someone has suicidal thoughts, they need human professionals to help. With years of training before we are licensed, we have specific ethical protocols to follow when a person reveals thoughts of suicide. Read the full article from US News & World Report here